Final report 2014-2018

  1. Creating and exploring new, exploitable and competitive biomaterials – nanostructured composite materials for bone and tissue implants.
  2. Develop and experimentally approbate new systems of optical biosensors for rapid microbiological quality control of food and environmental samples.
  3. Creating and exploring new, exploitable and competitive nano- and micro- carriers for targeted drug transport.

No

Activity of the project

Description

Result

1.

Development of methodology

The synthesis of Sr, Si and Mg- substituted HAp, β-TCP and biphasic calcium phosphate. Assessment of the degree of substitution.

Developed methods

2.

Development of analytical methodology

In vitro determination of ion release kinetics into the environment of simulated body fluid and water.

Developed methods

3.

Development of innovative micro- carriers for targeted drug transport

New, exploitable and competitive nano- and micro- carriers for targeted drug transport.

Developed methods (

4.

Development of technology

Development of methodology of preparation of substituted/unsubstituted calcium deficient CaP nanosuspension for bone regeneration.

Developed technology

5.

Development of technology for creation of innovative implants

Development of technologies for implants prototypes preparation.

Developed technologies

6.

Creation of new innovative nanostructured composite materials

Synthesis of calcium deficient nano-HAp in biocompatible polymer solutions, in situ synthesis of polymer/HAp hybrid-composites

Developed methods

7.

Evaluation of implants biocompatibility

In vitro evaluation of cell behavior on the obtained nanohybrid- composites

Developed methods

8.

Evaluation of implants functionality

In vivo evaluation of bone volume increase, rremineralization and reossification.

Developed methods

9.

Creation of prototype

Materials and methods for enhancement of bone volume and mechanical properties.

Prototypes developed

10.

Creation of prototype

Materials and methods for bone remineralization.

Prototypes developed

11.

Creation of prototype

Materials and methods for bone reossification - conversion of bones remodeling from atrophy to formation of new bone.

Prototypes developed

12.

Optical identification methodology

Development of rapid tools for optical identification of various environmental and food microbiological pollutants.

Developed methods

13.

Method for rapid identification of specific biosensors

Rapid identification of specific biosensors in various environmental and food samples with the developed tools.

Summary of results

14.

Development of laser tweezers

Laser tweezers setup and approbation for microrheological measurements

Laser tweezers

15.

Preparation of magnetoliposomes

Synthesis of magnetoliposomes nano- carriers of new kind for targeted transport

A new type of nanocarriers

for targeted transport

16.

Development of setupt for determination of magnetic microrheology

Setup for microrheological measurements – determination of viscoelastic properties of Pf1 gels

A device

17.

Ferrite nanocolloids

Synthesis of nanocolloids by chemical co-precipitation

Developed methods

18.

Nanocolloids of ferromagnetic metals

Preparation of ultra-small nanoparticles by spark erosion

Developed methods

 

PUBLISHED SCIENTIFIC PAPERS:

In journals with SNIP > 1

1.period

1. D.Loca, M.Sokolova, J.Locs, A.Smirnova, Z.Irbe. Calcium phosphate bone cements for local vancomycin delivery. Mater. Sci. Eng. C, 2015, 49, 106-113.(SNIP 1.144)

2. S. Grybauskas, J. Locs, I. Salma, G. Salms, L. Berzina-Cimdina. Volumetric analysis of implanted biphasic calcium phosphate/collagen composite by three-dimensional cone beam computed tomography head model superimposition. J. Cranio. Maxill. Surg., 2015, 43 (1), pp. 167-174.(SNIP 1.851)

3. P.A.Janmey, D.R.Slochover, Yu-H.Wang, Qi Wen and A.Cēbers. Polyelectrolyte properties of filamentous biopolymers and their consequences in biological fluids. Soft Matter- 2014, v.10, 1439 (SNIP 1.219)

4. R.Taukulis, A.Cēbers. Diffusion in active magnetic colloids. JMMM – 2014,v.368,P.428-431 (SNIP 1.408)

5. M.Belovs, and A.Cebers. Relaxation of polar order in suspensions with Quincke effect. Phys.Rev.E, 2014, v.89, 052310. (SNIP 1.004)

6. A.Cēbers. Poiseuille flow of a Quincke suspension, Phys.Rev.E, 2014, v.90,032305 (2014) (SNIP 1.004)­

7. G.Kitenbergs,K.Ērglis,R.Perzynski,A.Cēbers. Magnetic particle mixing with micro-convection for microfluidics, JMMM, 2015,v.380,227-230. (SNIP 1.408)

8. A.Brasovs, J.Cimurs, K.Erglis, A.Zeltins,J.-F.Berret, A.Cebers. Magnetic microrods as tool for microrheology. Soft Matter – 2015, v.11,2563-2569 (SNIP 1.219)

9. G.Kitenbergs,A.Tatulcenkovs,K.Ērglis,O.Petrichenko,R.Perzynski and A.Cēbers. Magnetic field driven micro-convection in the Hele-Shaw cell: the Brinkman model and its comparison with experiment. J.Fluid Mech., 2015,v.774,170-191 (SNIP 1.639)

10. F.G.Ergin,B.B.Watz,K.Erglis,A.Cebers. Time-resolved velocity measurements in a magnetic micromixer. Experimental thermal and fluid science. – 2015,v.67,6-13. (SNIP 1.923)

11. J.Gorchon,J.Curiale,A.Cebers,A.Lemaitre,N.Vernier,M.Plapp, and V.Jeudy. Current-induced fingering instability in magnetic domain wall. Phys.Rev.B -2015,v.92,060411(R). (SNIP 1.204)

2.period

1. D.Loca, I.Narkevica, J.Ozolins, L.Berzina-Cimdina. "The effect of TiO2 nanopowder coating on in vitro bioactivity of porous TiO2 scaffolds" Materials Letters, Vol 159, 2015, pp. 309-312.

2. L.Stipniece, I.Narkevica, M.Sokolova, J.Locs, J.Ozolins. "Novel scaffolds based on hydroxyapatite/poly(vinyl alcohol) nanocomposite coated porous TiO2 ceramics for bone tissue engineering", Ceramics International, Vol 42, 2016, pp. 1530-1537. (SNIP 1,304)

3.period

1. K.Šalma-Ancāne, L. Stīpniece, Z.Irbe, Effect of biogenic and synthetic starting materials on the structure of hydroxyapatite bioceramics. Ceramics International, 2016, Vol.42, Iss.8, pp. 9504-9510. (SNIP 1,304)

2. F.Martinez-Pedero, A.Cebers, and P.Tierno. Orientational dynamics of colloidal ribbons self-assembled from microscopic magnetic ellipsoids. Soft Matter, Doi:10.1039/C5SM02823J (online 22.02.2016)-2016, v.12, 3688-3695. (SNIP 1.219)

3. F.Martinez-Pedrero, A.Cebers, and P.Tierno. Dipolar rings of microscopic ellipsoids: magnetic manipulation and cell entrapment. Phys.Rev.Applied (Editors suggestion) -2016, v.6,034002. (SNIP 1.406)

4.period

1. L. Stipniece, V. Stepanova, I.Narkevica, K.Salma-Ancane, K., A.R.Boyd, Comparative study of surface properties of Mg-substituted hydroxyapatite bioceramic microspheres, 2018, Journal of the European Ceramic Society, 38 (2), pp. 761-768. (SNIP 1.776)

2. L. Stīpniece, I. Narkevica, K. Šalma-Ancāne, Low temperature synthesis of nanocrystalline hydroxyapatite: effect of Mg and Sr content. Journal of the American Ceramic Society, 2017, 100 (4), pp. 1697-1706. (SNIP 1.369)

3. M. Pilmane, K. Salma-Ancane, D. Loca, J. Locs, L. Berzina-Cimdina, Strontium and strontium ranelate – historical review of some their functions. Materials Science and Engineering C, 2017, 78, pp. 1222-1230 (SNIP 1.176)

4. A.Dubnika, D. Loca, V. Rudovica, M.B. Parekh, L Berzina-Cimdina, Functionalized silver doped hydroxyapatite scaffolds for controlled simultaneous silver ion and drug delivery, 2017, Ceramics International, 43 (4), pp. 3698-3705. (SNIP 1.304)

5. J. Vecstaudza, J. Locs, Novel preparation route of stable amorphous calcium phosphate nanoparticles with high specific surface area. Journal of Alloys and Compounds, 2017, 700, pp. 215-222. (SNIP 1.321)

6. Narkevica, L. Stradina, L.Stipniece, E. Jakobsons, J. Ozolins, Electrophoretic deposition of nanocrystalline TiO2 particles on porous TiO2-x ceramic scaffolds for biomedical applications, 2017, Journal of the European Ceramic Society, 37 (9), pp. 3185-3193. (SNIP 1.776)

7. Narkevica, L. Stipniece, E.Jakobsons, I. Cakstina, J Ozolins, Electrically active and 3D porous TiO2-x ceramic scaffolds for bone tissue regeneration, 2017, Journal of the European Ceramic Society, 37 (2), pp. 833-840. (SNIP 1.776)

8. J.Erdmanis, G.Kitenbergs, R.Perzynski, A.Cēbers. Magnetic micro-dropletin rotating field: numeric simulation and comparison with experiment. Journ.Fluid Mech., 2017, v.821, 266-295. (SNIP 1.636).

9. D. Zablotsky, E. Blums, H. J. Herrmann, Self-assembly and rheology of dipolar colloids in simple shear studied using multi-particle collision dynamics, Soft Matter, 2017, 13, 6474—6489. (SNIP 1.219)

10. V. Sints, E. Blums, G. Kronkalns, K. Erglis, M.M.Maiorov, Experimental research of surfaced nanoparticle thermal transport in a porous medium, International J. Heat and Mass Transfer, 125 (2018), 580 -588. (SNIP 2.005)

In journals with SNIP < 1

1.period

1. F.G.Ergin, B.B.Watz, K.Erglis, A.Cebers. Modal analysis of magnetic microconvection, Magnetohydrodynamics, 2014,50, 339-352 (SNIP 0.387)

2. O.Petrichenko,A.Plotniece,K.Pajuste,V.Ose,A.Cēbers. Formation of magnetoliposomes using self-assembling 1,4-dihydropyridine derivative and maghemite γ-Fe2O3 nanoparticles. Chemistry of Heterocyclic Compounds -2015,v.51,672-677 (SNIP 0.350)

3. G.Kronkalns, M. M. Maiorov, V. Serga, A. Krumina, D. Karashanov, Preparation and Properties of Noble Metal/Magnetite Composite Nanoparticles, Magnetohydrodynamics, Vol. 50 (2014), No. 4, pp. 423–430. (SNIP 0.378)

2.period

1. I.Narkevica, A.Reinis, L.Bugovecka, I.Skadins, E.Sansonetti, J.Kroica, J.Ozolins. In vitro Bioactivity and Bacteriostasis Effect of Thermally Treated and UV-light Irradiated TiO2 Ceramics" Key Eng. Mater. (Vol 674, 2016, pp. 121-126); (SNIP 0.303)

2. L.Stipniece, K.Salma-Ancane, D.Loca, S.Pastare. Synthesis of strontium substituted hydroxyapatite through different precipitation routes. Key Eng. Mater. 2016, 674, 3-8. (SNIP 0.303)

3. V.Zalite, J.Locs. Characterization of different hydroxyapatite particles for tooth enamel remineralization. Key. Eng. Mat., 2016, 674, 139-144. (SNIP 0.303)

4. M. Polakovs, N. Mironova-Ulmane, A. Pavlenko, A. Aboltins, Determination of methemoglobin in human blood after ionising radiation by EPR, IOP Conf. Ser.: Mater. Sci. Eng. 77 (2015) 012028:1-5. doi:10.1088/1757-899X/77/1/012028 (SNIP 0.573)

5. V. Sints, E. Blums, M. Maiorov, G. Kronkalns, Diffusive and thermodiffusive transfer of magnetic nanoparticles in porous media, Eur. Phys. J. E, (2015) 38: 35 DOI 10.1140/epje/i2015-15035- http://www.ncbi.nlm.nih.gov/pubmed/25957178 (SNP 0.746)

3.period

1. L. Stīpniece, I. Narkevica, K. Šalma-Ancāne, D.Loča, Sr- and/or Mg- containing nanocrystalline hydroxyapatite: study from synthesis to calcined products. Key Engineering Materials, 2017, Vol.721, pp. 167-171. (SNIP 0.303)

2. V. Zālīte, J. Ločs, Characterization and Preparation of Calcium Phosphate Model Toothpaste for Tooth Enamel Remineralization. Key Engineering Materials, 2017, Vol.721, pp. 213.-218. (SNIP 0.303)

3. I. Narkevica, L. Stradina, L. Stipniece, J. Ozolins. Electrophoretic deposition of TiO2 nanoparticles on dense TiO2-x ceramic electrodes. Key Engineering Materials, 2017, 721, pp. 177-181. (SNIP 0.303)

4. M. Sokolova, J. Locs, D. Loca, Hyaluronan Hydrogel/Calcium phosphates composites for medical application. Key Engineering Materials, 2017, 721, pp. 219-223. (SNIP 0.303)

5. A.Vojevodova, D. Loča, Hydroxyapatite/Polyvinyl Alcohol Composite In Situ Synthesis for Hydrogel Formation, Key Engineering Materials, 2017,Vol. 721, pp. 202-207. (SNIP 0.303)

6. A. Dubnika, D. Loca, L. Berzina-Cimdina. Cross-linked Dexamethasone Sodium Phosphate Delivery Systems Based on Silver Doped Hydroxyapatite Scaffolds. Key Engineering Materials, 2017, Vol. 721, pp. 192-196. (SNIP 0.303)

7. I. Jurgelane, A. Buss, D. Loca. Bovine serum albumin adsorption onto hydroxyapatite and biphasic calcium phosphate ceramic granules. Key Engineering Materials, 2017,Vol. 271, 197-201. (SNIP 0.303)

8. Z. Irbe, D. Loca, A. Pura, L. Berzina-Cimdina, Synthesis and Properties of α-Tricalcium Phosphate from Amorphous Calcium Phosphate as Component for Bone Cements. Key Engineering Materials, 2017, Vol. 721, pp. 182-186. (SNIP 0.303)

9. K. Rubenis, J. Locs, Hydrothermal Synthesis of SnO2 Structures with Various Morphologies in the Presence of Different Alcoholic Co-Solvents. Key Engineering Materials, 2017, Vol. 721, pp. 87-91. (SNIP 0.303)

10. J. Vecstaudža, J. Ločs, Effect of Synthesis Temperature and Ca/P Ratios on Specific Surface Area of Amorphous Calcium Phosphate. Key Engineering Materials, 2017, Vol.721, pp.172-176. (SNIP 0.303)

11. J. Zarins, M. Pilmane, I. Salma, K. Make, Quantitative Changes of Bone Volume and Immunohistochemical Analysis of Biomarkers in Healthy, Osteoporotic and Osteoporotic Sham Surgery Affected Rabbit Bone Controls. Key Engineering Materials, 2017, Vol. 721, pp. 234-239. (SNIP 0.303)

12. S. Petronis, J. Ločs, V.Zālīte, M. Pilmane, A.Skaģers, I. Šalma, Impact of Biphasic Calcium Phosphate Bioceramics on Osteoporotic Hip Bone Mineralization in vivo Six Months after Implantation. Key Engineering Materials, 2017, Vol.721, pp. 229.-233. (SNIP 0.303)

13. A.Grisulonoks, I. Cakstina, A. Abolins, J. Locs, A. Skagers, I. Salma, G. Salms and V. Klimec, Response of Osteoporotic Jaw Bone to Implantation of Biphasic Calcium Phosphate Bioceramics Supplemented with Autologous Mesenchymal Cells. Key Engineering Materials, 2017, Vol. 721, pp. 240-244. (SNIP 0.303)

14. G. Salms, V. Ananjevs, V. Kasyanovs, A. Skagers, I. Salma, J. Vetra, V. Zalite, L. Stipniece, S. Petronis, Change of Biomechanical Parameters in the Lower Jaws of Rabbits with Experimental Osteoporosis after Implantation of Calcium-Phosphate Bioceramic Material in the Greater Trochanter Region. Key Engineering Materials, 2017, Vol. 721, pp. 224-228 (SNIP 0.303)

15. L. Mezule, T. Juhna , Effect of labile organic carbon on growth of indigenous Escherichia coli in drinking water biofilm. Chemical Engineering Transactions, 2016, Vol. 49, pp. 619-624. (SNIP 0.584)

16. M.Belovs, and A.Cēbers. Hydrodynamics with spin in bacterial suspensions. Phys.Rev.E- 2016, 93,062404, 10.1103/PhysRevE.93.062404.

17. M. Maiorov, E. Blums, G. Kronkalns, A. Krumina, M. Lubane, Magnetite Nanoparticles prepared by Spark Erosion. Journal of Engineering Latvian and Physical Sciences, 2016, DOI: 10.1515/lpts-2016-0026. (SNIP 0.653)

4.period

1. L. Robinson, K. Šalma-Ancāne, L. Stīpniece, B.J. Meenan, A.R. Boyd, The deposition of strontium and zinc co-substituted hydroxyapatite coatings. Journal of Materials Science: Materials in Medicine, 2017, 28 (3), art. no. 51 (SNIP 0.739)

2. Z. Irbe,A. Bušs, D.Loča, L.Mālniece, Synthesis of Amorphous Calcium Phosphate as a Starting Material for α-Tricalcium Phosphate. Solid State Phenomena, 2017, Vol.267, pp.119-123. (SNIP 0.478)

3. Janis Zarins, Mara Pilmane, Elga Sidhoma, Ilze Salma, Janis Locs. Local and Systemic Morphofunctional Response of Osteoporotic Rabbits Bone Defect Following Implantation of Strontium Doped Biphasic Ceramic Granules. Solid State Phenomena. 2017; Vol. 267, pp 124-131. (SNIP 0.478)

4. H.Massana-Cici, F.Martinez-Pedrero, A.Cebers, P.Tierno. Orientational dynamics of fluctuating dipolar particles assembled in a mesoscopic colloidal ribbon. Phys.Rev.E., - 2017, v.96, 012607 (SNIP 0.896)

5. G. Kronkalns, E. Blums, M.M. Maiorov, V. Serga, A. Krumina, Preparation and Properties of Gadolinium/Noble Metal Fine Particle preparation and properties, Magnetohydrodynamics, 52 (2016), 4, pp. 535-539, (publicēts 2017. g.). (SNIP 0.481)

SUBMITTED SCIENTIFIC PAPERS:

4.period

1. Z. Irbe, D. Loca, D. Vempere, L. Berzina-Cimdina, Synthesis and Properties of α-Tricalcium Phosphate from Amorphous Calcium Phosphate as Component for Bone Cements,) gatavojas iesniegt citā žurnālā. ACS Biomaterials Science and Engineering.

2. Janis Zarins, Mara Pilmane, Elga Sidhoma, Ilze Salma, Janis Locs, Reactogenicity of ovariectomized rabbits bone 12 weeks after implantation of hydroxyapatite and tricalcium phosphate granules eNoiched with strontium and comparison to healthy bone. Journal of Materials Science: Materials in Medicine.

3. A. Grisulonoks, I. Salma, A. Skagers, J. Locs. Response of osteoporotic bone to the implantation of biphasic calcium phosphate (BCP) bioceramic. Key Enginering Materials. (SNIP 0.303)

1. M.Belovs, R.Livanovics, A.Cēbers. Hydrodynamic synchronization in swarms of asynchronous magnetotactic bacteria subject to a rotating magnetic field (iesn.Phys.Rev.Fluids)

2. O.Petrichenko, K.Pajuste, A.Plotniece, M.Rucins, A.Cēbers, magnetic formation ability depending on the structure of athionic pyridium amphiphiles, Abstract book, Drug Discovery Conference, August 27-29, 2015, Riga Latvia, pp.130. 2

3. O.Petrichenko,A.Cēbers, K.Pajuste, A.Plotniece, V.Ose, Ferromagnetic nanoparticles and their functionalization, Abstract book, EuroNanoForum, 10-12 June 2015, Riga, Latvia.

4. G. Kronkalns, M. Maiorov, V. Serga, A. Cvetkovs, A. Krumina, D.Karashanova, Preparation and Properties of Platinum Coated Magnetite Nanoparticles, , in: The 9th International Pamir Conference on Fundamental and Applied MHD, Thermo Accoustic and Space Technologies, Riga, Latvia, June 16-20, 2014, Vol. 2, p. 288-292.

5. V. Sints, E. Blums, M. M. Maiorov, G. Kronkalns, O. Petricenko, Experimental Investigation of Magnetic Nanoparticle Transfer Within a Porous Medium and under Influence of a Magnetic Field, in: The 9th International Pamir Conference on Fundamental and Applied MHD, Thermo Accoustic and Space Technologies, Riga, Latvia, June 16-20, 2014, Vol. 2, p. 306-210.

6. D. Jakovlevs, M. Polakovs, N. Mironova-Ulmane, V. Skvortsova, L. Berzina-Cimdina, I. Sildos. Gallstones Studies by Raman, EPR and EDX Spectroscopes. Procceding internatiol conference RCBJSF-2014 -FM&NT, Riga, Latvia, 29.-02.10.2014. P. 354.

7. Maksims Polakovs, Nina Mironova-Ulmane, Andreijs Pavlenko Ainars Aboltinš Determination of methemoglobin in human blood after ionising radiation by EPR. Procceding internatiol conference RCBJSF-2014 -FM&NT, Riga, Latvia, 29.-02.10.2014. P.356.

8. Maris Ozolinsh, Paulis Paulins, Varis Karitans, Gunta Krumina “Smart Model Eye on Base of PDLC for Continued Stage Cataract Studies”. Abstr.Book RCBJSF–2014–FM&NT Conf., Riga, p.368.

9. Ilze Šalma, Māra Pilmane, Ģirts Šalms, Jānis Ločs, “Biokeramikas un polimēru kompozītmateriālu izmantošana kaulaudu aizvietošanā in vivo eksperimentā”, RSU Zinātniskā konference, 26.-27.03. 2015, Rīga, Latvija, 302.lpp.

2.period

1. Olga Danilenko, Maris Ozolinsh, Varis Karitans. “SmartGlass” in studies of eye scattering. Submitted in: Material Science (ISSN 2029–7289).

2. Maris Ozolinsh, Paulis Paulins, and Varis Karitans. Smart model eye on base of polymer dispersed liquid crystals and CMOS sensor. Proc. DOC-2015, Riga Apr.2015, p.35; http://docriga.lv/assets/5521945957070/DOC-2015-book-of-abstracts.pdf

3. Olga Danilenko, Maris Ozolinsh, Varis Karitans, “Light Scatterig "Smart Glass" in Vision Science”. Book of abstracts of the 17-th International Conference-School Advanced Materials and Technologies. Palanga, p. 126 (2015)

4. Olga Danilenko, Maris Ozolinsh and Daniel Baker “Time course and interocular transfer of size and contrast adaptation aftereffects.” Book of abstracts of the AVA-2015, London, p. 8 (2015); www.theava.net/meetings/Abstract_book.pdf.

5. Daļecka B., Mežule L., Comparison of various DNA extraction methods for Fusarium solani detection and enumeration with real-time PCR. Microbes in the spotlight: recent progress in the understanding of beneficial and harmful microorganisms, BrownWalker Press, Pieņemts.

6. V. Sints, E. Blums, G. Kronkalns, M. M. Maiorov, Temperature Driven Surfaced Colloidal Particle Transfer in a Porous Environment, in: Advances in Heat Transfer, Proc. 7th Baltic Heat Transfer Conference, August 24-26, 2015, Tallinn, Estonia, eds. D. Neshumayev, B. Sunden, pp. 227 – 232.

7. M Sokolova, J Locs, A Putnins “Degradation behaviour of biodegradable biopolymer and calcium phosphates composites”, European Cells and Materials Vol. 29. Suppl. 1, 2015 (page 56), ISSN 1473-2262.

3.period

1. V. Anaņjevs, A. Skaģers, I.Šalma, Ģ. Šalms, J. Vētra, V. Vītiņš, V. Zālīte, L.Stīpniece, V. Kasjanovs, Osteoporotisku apakšžokļa kaulu biomehānisku rādītāju izmaiņas pēc lokālas pastiprināšanas ar bifāziskajiem kalcija fosfātu biokeramikas materiāliem augšstilba trochanter majus rajonā (eksperimentāls pētījums). Zinātniska publikācija RSU Zinātniskie raksti, 2016, 6 lpp.

2. M.Maiorov, E. Blums, G. Kronkalns, A. Krumina, M. Lubane, Magnetic nanoparticles prepared by spark discharge. Proceedings of the 10th PAMIR International Conference Fundamental and Applied MHD, June 20–24, 2016 Cagliari, Italy, 5 pages.

4.period

1. B. Dalecka, L. Mezule, T. Juhna, Study of potential PCR Inhibitors in Drinking Water from Riga Distribution System. No: Uniting Europe for Clean Water: Cross-Border Cooperation of Old, New and Candidate Countries of EU for identifying problems, finding causes and solutions. Book of abstracts., Ungārija, Budapest, 25.-27. maijs, 2017. Budapest: Budapest University of Technology and Economics, Department of Applied Biotechnology and Food Science, 2017, 159.-160.lpp. ISBN 978-963-313-256-2.

MONOGRAPHYS:

1.period

1. D.Loca, J.Locs, A.Dubnika, V.Zalite, L.Berzina-Cimdina. Hydroxyapatite (HAP) for biomedical applications: Chapter 9. Porous hydroxyapatite for drug delivery. Woodhead Publishing Ltd., Editor: Michael Mucalo, 2015, 129-142.

3.period

1. M. Lēruma, L. Bērziņa-Cimdiņa. From the Development of Beer Fermentation, Soap Making to the Technology of Biomaterials and Ecomaterials, Rīga: RTU Izdevniecība, 2016. – 158 lpp.

PhD THESIS:

1.period

1. Arita Dubņika „Controlled release drug delivery systems based on silver doped hydroxyapatite”, defended in 2014.

2. Kristīne Ruģele “Anaerobic Digestion of Dairy Residues and Process Enhancement Using Composite Materials from Industrial Wastes”, defended in 2015.

3. G.Kitenbergs “Hydrodynamic instabilities in microfluidic magnetic flows”, defended in 2015.

4. Jānis Cīmurs “Domain and superparamagnetic particle dynamics in time dependent magnetic fields”, defended in 2015

5. Kaiva Juraševska ”Development of a psychological pseudosochromatic test and evalution of color sicrimination threshold”, defended in 2015.

3.period

1. Līga Stīpniece. Development of Magnesium Modified Calcium Phosphate bioceramic for Bone Tissue Regeneration. Supervisors: Prof., Dr.sc.ing. Līga Bērziņa-Cimdiņa, Lead.Res., Dr.sc.ing. Kristīne Šalma-Ancāne. Defended RTU, 2016.12.14.

2. Jolanta Vamze-Liepiņa. Characteristics of reactogenicity in distant time periods after implantation of bone tissue substituting biomaterials. Supervisors: Prof., Dr. habil. med. Māra Pilmane, Prof., Dr. habil. med. Andrejs Skaģers. Defended RSU 2016.07.07.

3. Ingus Skadiņš. Antibacterial efficiency of antibiotic-impregnated biomaterials in an in vitro and in vivo study. Supervisors: Prof., Dr. med. Juta Kroiča, doc., Dr. med. Ilze Šalma. Defended RSU 2016.11.07.

4. Aigars Reinis. Determination of adhesion and colonisation intensity of Staphylococcus epidermidis and Pseudomonas aeruginosa on the surface of originally synthesised biomaterials in vitro and in vivo studies, and their impact on inflammatory cytokine expression in tissues. Supervisors: Prof., Dr. habil. med. Jānis Vētra, Prof., Dr. med. Juta Kroiča. Defended RSU 2016.11.07.

5. Rūdolfs Livanovičs. The mathematical modeling of the single and ensemble dynamics of magnetic filaments. Supervisors: Prof., Dr. habil. phys. Andrejs Cebers. Defended LU 2016.01.22.

4.period

1. Kristaps Rubenis, Obtaining of tin dioxide based materials, characterization of structure and physical properties. Supervisor: Dr.sc.ing. Dagnija Loča. Defended RTU, 2017.

2. Vita Zālīte, Synthesis of Strontium and Fluorine Substituted Calcium Deficient Hydroxyapatite and Application for Tooth Enamel Remineralization. Supervisor: Dr.sc.ing. Jānis Ločs. Defended RTU, 2017.

MASTER’S THESIS:

1.period

1. Jana Vecstaudža “Effect of titanium dioxide on crystallization of Na2O-CaO-Nb2O5-P2O5 system glasses”, defended in 2014.

2. Andris Putniņš “Technology for production of tailored shape calcium phosphate granules”, defended in 2014.

2.period

1. Svetlana Azareviča. Synthesis and characterization of magnesium and strontium containing amorphous apatites. Supervisor: Kristīne Šalma-Ancāne, consultant: Līga Stīpniece. Defended in RTU on June, 2015.

2. Jūlija Kozela. Use of calcium phosphates for tooth enamel remineralization. Supervisors: J.Ločs, V.Zālīte. Defended in RTU on June, 2015.

3. Lāsma Puķina Optically induced magnetic unstabilities in magnetic fluids, University of Latvia, Faculty of Physics and Mathematics, Physics department, Master thesis, 58 p., Riga, 2015.

4. Daņiļenko Olga. Vision contrast adaptation and aftereffect mechanisms. Supervisor: M.Ozoliņš. Defended in University of Latvia on June, 2015.

5. Alisa Dorofejeva. Diurnal rhythms of eye iris response. Supervisor: S.Fomins. Defended in University of Latvia on June, 2015

6. Agnese Ķiršteine. Response of the eye iris to different illumination. Supervisor: S.Fomins. Defended in University of Latvia on June, 2015.

7. Lukjanovs Juris. Maesuring of eye tear film. Supervisor: Varis Karitāns. Defended in University of Latvia on June, 2015.

3.period

1. Ilze Balode, Composites of hyaluronic acid and calcium phosphates. Supervisors: Dr. sc.ing., asoc.prof. Jānis Ločs, Mg.sc.ing., res. Marina Sokolova. Defended RTU, 2016.

2. Anastasija Smirnova, Preparation and characterization of strontium ranelate/polylactic acid containing microcapsules. Supervisor: Dr.sc.ing. Dagnija Loča. Defended RTU, 2016.

3. Aleksandrs Mirošņikovs, Development of biodegradable polymer/calcium phosphate composite materials. Supervisors: Dr. sc.ing., asoc.prof. Jānis Ločs, Mg. sc.ing., res. Marina Sokolova. Defended RTU, 2016.

4. Laura Stradiņa, Electrophoretic deposition of TiO2 nanoparticles on TiO2-x ceramic electrodes. Supervisors: Dr. sc.ing., prof. Jurijs Ozoliņš, Mg. sc. ing., res. Inga Narkevica. Defended RTU, 2016.

5. Lauma Bugovecka, The impact of different factors on the properties of titanium dioxide for potential use in bone tissue regeneration. Supervisors: Dr. sc.ing., prof. Jurijs Ozoliņš, Mg. sc.ing., res. Inga Narkevica. Defended RTU, 2016.

6. Mārīte Bižāne, Zero eradication of Legionella in internal water supply networks of apartment buildings. Supervisor: Dr.sc.ing. Linda Mežule. Defended RTU, 2016.

7. Jānis Erdmanis, Balance shapes and dynamics of the magnetic field in the outer liquid drop. Supervisor: Prof., Dr. habil. phys. Andrejs Cebers. Defended LU, 2016.

4.period

1. Anna Vojevodova, Hydrogels of hydroxyapatite/polyvinyl alcohol composite materials for bone and cartilage tissue engineering. Supervisor: Dr.sc.ing., doc. Dagnija Loča. Defended RTU, 2017.

CONFERENCES:

1.period

1. Līga Bērziņa-Cimdiņa, Nanomaterials and nanotechnologies for medical applications. 56th International Scientific Conference of Riga Tecnical University, October 14-16, Riga, Latvia.

2. Ilze Šalma, Application of biomaterials for experimental treatment of osteoporosis, 56th International Scientific Conference of Riga Tecnical University, October 14-16, Riga, Latvia.

3. Ilze Šalma, Māra Pilmane, Ģirts Šalms, Jānis Ločs, Biokeramikas un polimēru kompozītmateriālu izmantošana kaulaudu aizvietošanā in vivo eksperimentā, RSU Zinātniskā konference, 26.-27.03. 2015, Rīga, Latvija, 302.lpp.

4. I.Narkevica, L.Stradina, L.Bugovecka, J.Locs, J.Ozolins, L.Berzina-Cimdina. Enhanced in vitro apatite-forming ability of porous TiO2 scaffolds. 26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics 26), Barcelona, Spain, 06-09.11.2014.

5. I.Narkevica, J.Ozolins, L.Berzina-Cimdina. 3D porous titania ceramic scaffolds for bone tissue regeneration. Unified scientific approaches towards regenerative orthopaedics and dentistry (REDEOR), Venice, Italy, 24.03-28.03.2015

6. V. Sints, E. Blums, M. M. Maiorov, G. Kronkalns, O. Petricenko, “Experimental Investigation of Magnetic Nanoparticle Transfer within a Porous Medium and under Influence of a Magnetic Field”, The 9th International Pamir Conference on Fundamental and Applied MHD, Thermo Accoustic and Space Technologies”, Riga, Latvia, June 16-20, 2014.

7. Mara Pilmane, Jolanta Vamze, Ilze Salma, Girts Salms, Dagnija Loca, Janis Locs, Zilgma Irbe “Bone regeneration, local defence and apoptosis characterization in rabbit lower jaw after different pH calcium phosphate cementum implantation”, Unified scientific approaches towards regenerative orthopaedics and dentistry, 25.-27. 03. 2015. Venice, Italy. Stenda referāts.

8. Ilze Šalma, Māra Pilmane, Ģirts Šalms, Jānis Ločs, “Biokeramikas un polimēru kompozītmateriālu izmantošana kaulaudu aizvietošanā in vivo eksperimentā”, RSU Zinātniskā konference, 26.-27.03. 2015, Rīga, Latvija.

9. I. Salma, M. Pilmane, J. Locs, G. Salms, “Morphometric analysis and immunohistochemical evaluation of tricalcium phosphate (TCP) scaffolds in vivo”, 8th Annual meeting of the Scandinavian Society for Biomaterials, 6.-8. 05. 2015. Sigulda, Latvija. Stenda referāts.

10. G. Salms, S Grybauskas, J Locs, I Salma, “Volumetric analysis of malar augmentation with biphasic calcium phosphate”. 8th Annual meeting of the Scandinavian Society for Biomaterials, 6.-8. 05. 2015. Sigulda, Latvija.

11. D. Jakovlevs, M. Polakovs, N. Mironova-Ulmane, V. Skvortsova, L. Berzina-Cimdina, I. Sildos. Gallstones Studies by Raman, EPR and EDX Spectroscopes. International conference RCBJSF-2014 -FM&NT, Riga, Latvia, 29.-02.10.2014.

12. Maksims Polakovs, Nina Mironova-Ulmane, Andreijs Pavlenko Ainars Aboltinš Determination of methemoglobin in human blood after ionising radiation by EPR. International conference RCBJSF-2014 -FM&NT, Riga, Latvia, 29.-02.10.2014.

13. Maris Ozolinsh, Paulis Paulins, Varis Karitans, Gunta Krumina “Smart Model Eye on Base of PDLC for Continued Stage Cataract Studies”. International conference RCBJSF–2014–FM&NT Conf., Riga, p.368.

2.period

1. Maris Ozolinsh, Paulis Paulins, and Varis Karitans. Smart model eye on base of polymer dispersed liquid crystals and CMOS sensor. Developments in Opticals and Communications - 2015, Riga, Apr. 2015.

2. Narkevica, L.Bugovecka, J.Ozolins “In vitro bioactivity studies of thermally treated titanium dioxide ceramics”. Scandinavian Society for Biomaterials 8th Annual Meeting, 06.- 08.05.2015., Sigulda, Latvija

3. M.Sokolova, J.Locs. “Degradation behaviour of biodegradable biopolymer and calcium phosphates composites”. Scandinavian Society for Biomaterials 8th Annual Meeting, 06.- 08.05.2015., Sigulda, Latvija

4. E. Blums “Magnetite Nanoparticles Prepared by Spark Erosion”. 7th International Conference on Nanotechnology and Advanced Materials, EuroNanoForum 2015, Riga, Latvia, 10-12.6.2015

5. V. Sints “Thermal transport of lyophilized nanoparticles in porous media”. 7th International Conference on Nanotechnology and Advanced Materials, EuroNanoForum 2015, Riga, Latvia, 10-12.6.2015.

6. Olga Danilenko, Maris Ozolinsh, Varis Karitans, “Light Scatterig "Smart Glass" in Vision Science”. Book of abstracts of the 17-th International Conference-School Advanced Materials and Technologies. Palanga, p. 126 (2015)

7. V. Sints “Temperature Driven Surfaced Colloidal Particle Transfer in a Porous Environment”. 7th Baltic Heat Transfer Conference, Tallinn, August 21-24.

8. K. Salma-Ancane, L.Stipniece, I.Narkevica, I. Juhnevica, L. Berzina-Cimdina “Development of Nanostructured Composites Based on ɛ-Polylysine and Apatite” 27th European Conference on Biomaterials ESB2015, Krakow, Poland, 30.08-03.09.2015.

9. I. Salma, S. Petronis, M. Pilmane, A. Skagers, V. Zalite, J. Locs “Local recovery of bone tissue in osteoporotic rabbit hip after implantation of HAP/TCP bioceramic granules” 27th European Conference on Biomaterials ESB2015, Krakow, Poland, 30.08-03.09.2015.

10. I.Narkevica, L.Stradina, L.Liepkaula, J.Ozolins “Preparation of Electroconductive Titania Scaffolds for Bone Tissue Regeneration” 27th European Conference on Biomaterials ESB2015, Krakow, Poland, 30.08-03.09.2015.

11. I.Narkevica, L.Stradina, L.Liepkaula, J.Ozolins “Development of innovative 3D porous TiO2 ceramic scaffolds for orthopaedic applications”. The Eleventh Conference for Young Scientists in Ceramics, SM-2015, Novi Sad, Serbia, October 21-24, 2015.

12. L.Stīpniece, K.Šalma-Ancāne, D.Loča, S.Pastare. Synthesis of strontium substituted hydroxyapatite through different precipitation routes. 24th International Baltic Conference ENGINEERING MATERIALS & TRIBOLOGY BALTMATTRIB 2015, Tallin, Estonia, November 5-6, 2015.

13. I.Narkevica, A.Reinis, L.Bugovecka, E.Sansonetti, J. Kroica, J.Ozolins ”In vitro Bioactivity and Bacteriostasis Effect of Thermally Treated and UV-light Irradiated TiO2 Ceramics. 24th International Baltic Conference ENGINEERING MATERIALS & TRIBOLOGY BALTMATTRIB 2015, Tallin, Estonia, November 5-6, 2015.

14. V.Zālīte un J. Ločs “Characterization of different hydroxyapatite particles for tooth enamel remineralization”. 24th International Baltic Conference ENGINEERING MATERIALS & TRIBOLOGY BALTMATTRIB 2015, Tallin, Estonia, November 5-6, 2015.

15. J. Vecstaudza, J. Locs “Rapid reprecipitation of nanosized calcium phosphates”. 24th International Baltic Conference ENGINEERING MATERIALS & TRIBOLOGY BALTMATTRIB 2015, Tallin, Estonia, November 5-6, 2015.

16. Z.Irbe, D.Loča, D.Vempere, L/bērziņa-Cimdiņa “Alkali phosphates as setting aids for α-tricalcium phosphate-glycerine bone cements pastes”. 24th International Baltic Conference ENGINEERING MATERIALS & TRIBOLOGY BALTMATTRIB 2015, Tallin, Estonia, November 5-6, 2015.

17. Ilze Šalma "RSU un RTU zinātniskie projekti". RSU Zinātnes dienas 2015.

18. Olga Danilenko, Maris Ozolinsh and Daniel Baker “Time course and interocular transfer of size and contrast adaptation aftereffects.” Proc.Applied Vision Association-2015, London Dec.2015

19. L.Stīpniece, K.Šalma-Ancāne, J.Ločs, O.E. Sigurjonsson “Mg containing biphasic calcium phosphate bioceramics: preparation and in vitro evaluation”. 40th International Conference and Expo on Advanced Ceramics and Composites (ICACC’16), Daytona Beach, Florida, ASV, 24.-29.janāvāris, 2016.

20. I.Narkevica, L.Stipniece, J.Ozolins "Hydroxyapatite/poly(vinyl alcohol) nanocomposite coated TiO2 scaffolds for bone tissue engineering".40th International Conference and Expo on Advanced Ceramics and Composites (ICACC’16), Daytona Beach, Florida, ASV, 24.-29.januāris, 2016

3.period.

1. L. Stīpniece, I. Narkevica, K. Šalma-Ancāne, L. Bērziņa-Cimdiņa, Development and characterization of Mg-containing hydroxyapatite, β-tricalcium phosphate and biphasic calcium phosphate bioceramics. Eighteenth annual conference YUCOMAT 2016, Montenegro, Herceg Novi, September 5-10, 2016.

2. I. Narkevica, L. Stipniece, J. Ozolins, Design and characterization of hydroxyapatite/poly(vinyl alcohol) nanocomposite coated titania scaffolds for bone repair. Eighteenth annual conference YUCOMAT 2016, Montenegro, Herceg Novi, September 5-10, 2016.

3. I. Narkevica, J. Ozolins, I. Cakstina, I. Skadins ”Fabrication and characterization of modified titanium dioxide scaffolds for bone tissue engineering”. Scandinavian Society for Biomaterials 9th conference (ScSB 2016), Iceland, Reykjavik, June 1-3, 2016.

4. L. Stīpniece, K. Šalma-Ancāne, I. Narkevica, V. Rjabovs, Development of hydroxyapatite/modified poly(vinyl alcohol) composites for bone tissue engineering. Scandinavian Society for Biomaterials 9th conference (ScSB 2016), Iceland, Reykjavik, June 1-3, 2016.

5. I. Šalma, Morphological and radiological evaluation of bone in animals with experimental osteoporosis after implantation of HAP/TCP bioceramic granules. Scandinavian Society for Biomaterials 9th conference (ScSB 2016), Iceland, Reykjavik, June 1-3, 2016.

6. K. Šalma-Ancāne, L.Stīpniece, J.Ločs, L.Bērziņa-Cimdiņa, Fabrication of Novel Composites Based on ε-Polylysine and Hydroxyapatite. Bioceramics28, USA, North Carolina, Charlotte, October 18-21, 2016.

7. L. Stīpniece, I. Narkevica, K. Šalma-Ancāne, D. Loča, Sr- and/or Mg- Containing Nanocrystalline Hydroxyapatite: Study from Synthesis to Calcined Products. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

8. I. Narkevica, L. Stradina, J. Ozolins, Electrophoretic deposition of TiO2 nanoparticles on TiO2-x ceramic electrodes. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

9. L. Stīpniece, V.Rjabovs, I. Narkevica, K. Šalma-Ancāne, J. Ločs, Development of nano-hydroxyapatite/poly(vinyl alcohol) hybrid systems for prospect drug delivery applications. COST Action MP1301 Newgen „Hydrogel / Biomineralized Biomaterial for Bone tissue Regeneration”, Checz Republic, Zlin, November 15-16, 2016.

10. M.Sokolova, J.Locs, D.Loca, Hyaluronan Hydrogel/Calcium phosphates composites for medical application. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

11. A. Dubnika, D. Loca, L. Berzina-Cimdina, Cross-linked Dexamethasone Sodium Phosphate Delivery Systems Based on Silver Doped Hydroxyapatite Scaffolds. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

12. I. Jurgelane, A. Buss, D. Loca, Bovine serum albumin adsorption onto hydroxyapatite and biphasic calcium phosphate ceramic granules. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

13. K. Rubenis, J. Locs, Hydrothermal Synthesis of SnO2 Structures with Various Morphologies in the Presence of Different Alcoholic Co-Solvents. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

14. V.Zālīte, J. Ločs, Characterization and Preparation of Calcium Phosphate Model Toothpaste for Tooth Enamel Remineralization. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

15. A.Vojevodova, D.Loča, Hydroxyapatite/Polyvinyl Alcohol Composite In Situ Synthesis for Hydrogel Formation. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

16. Z. Irbe, D. Loca, A. Pura, L. Berzina-Cimdina, Synthesis and Properties of α-Tricalcium Phosphate from Amorphous Calcium Phosphate as Component for Bone Cements. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

17. J. Vecstaudža, J. Ločs, Effect of Synthesis Temperature and Ca/P Ratios on Specific Surface Area of Amorphous Calcium Phosphate. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

18. J. Zarins, M. Pilmane, I. Salma, K. Make, Quantitative Changes of Bone Volume and Immunohistochemical Analysis of Biomarkers in Healthy, Osteoporotic and Osteoporotic Sham Surgery Affected Rabbit Bone. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

19. A. Grisulonoks, I. Cakstina, A. Abolins, J. Locs, A. Skagers, I. Salma, G. Salms and V. Klimecs, Response of Osteoporotic Jaw Bone to Implantation of Biphasic Calcium Phosphate Bioceramics Supplemented with Autologous Mesenchymal Cells. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

20. G. Salms, V. Ananjevs, V. Kasyanovs, A. Skagers, I. Salma, J. Vetra, V. Zalite, L. Stipniece, S. Petronis, Change of Biomechanical Parameters in the Lower Jaws of Rabbits with Experimental Osteoporosis after Implantation of Calcium-Phosphate Bioceramic Material in the Greater Trochanter Region. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

21. S. Petronis, J. Ločs, V. Zālīte, M. Pilmane,A. Skaģers, I. Šalma, Impact of Biphasic Calcium Phosphate Bioceramics on Osteoporotic Hip Bone Mineralization in vivo Six Months after Implantation. 25th International Baltic Conference of Engineering Materials & Tribology (Baltmattrib 2016), Latvia, Riga, November 3-4, 2016.

22. M. Pilmane, Cellular response in rabbit osteoporotic and healthy bone for intact and sham control in biomaterial implantation. TERMIS AP 2016 (Audu inženierijas un reģeneratīvās medicīnas starptautiskās asociācijas konference), 3.-6.09. 2016, Taivana.

23. L. Bērziņa-Cimdiņa, D. Loča, J. Ločs, Nanomateriāli un nanotehnoloģijas medicīniskajam pielietojumam (VPP IMIS2 projekts No.4), Book of Abstracts, 32nd Scientific Conference of Institute of Solid State Physics, University of Latvia, Riga, Latvia, March 17-19, 2016, p. 113.

24. I. Šalma, M. Pilmane. Kaulaudu morfoloģisks un radioloģisks novērtējums dzīvniekiem ar eksperimentālu osteoporozi. Book of Abstracts, 32nd Scientific Conference of Institute of Solid State Physics, University of Latvia, Riga, Latvia, March 17-19, 2016, 114.lpp

25. I. Narkevica, L. Bugovecka, L. Stradiņa, J. Ozoliņš, L. Bērziņa-Cimdiņa, Porainas titāna dioksīda keramiskās pamatnes kaulaudu reģenerācijai. Book of Abstracts, 32nd Scientific Conference of Institute of Solid State Physics, University of Latvia, Riga, Latvia, March 17-19, 2016, p. 135.

26. L. Stīpniece, J. Vecstaudža, V. Zālīte, K. Šalma-Ancāne, D. Loča, L. Bērziņa-Cimdiņa, Kalcija fosfātu dizains un sintēzes optimizācija biomedicīniskam pielietojumam. Book of Abstracts, 32nd Scientific Conference of Institute of Solid State Physics, University of Latvia, Riga, Latvia, March 17-19, 2016, p. 136.

27. M. Sokolova, L. Stīpniece, A.Vojevodova, A. Mirošņikovs, K. Šalma-Ancāne, J. Ločs, L. Bērziņa-Cimdiņa, Bionoārdāmi kompozītmateriāli un polimēri uz kalcija fosfātu bāzes medicīniskam pielietojumam: izstrādes tehnoloģijas un raksturojums. Book of Abstracts, 32nd Scientific Conference of Institute of Solid State Physics, University of Latvia, Riga, Latvia, March 17-19, 2016, p. 137.

28. K. Rubenis, J. Ločs, Ar dzirksteļizlādes plazamas saķepināšanas metodi iegūtas Sb aizvietotas SnO2 keramikas termoelektriskās īpašības. Book of Abstracts, 32nd Scientific Conference of Institute of Solid State Physics, University of Latvia, Riga, Latvia, March 17-19, 2016, p. 138.

29. L. Bērziņa-Cimdiņa, Valsts Pētījumu programmas IMIS2 4.projekts “Nanomateriāli un nanotehnoloģijas medicīniskam pielietojumam”, Proceedings materials Science and Applied Chemistry, Riga Technical University 57th International Scientific Conference, Riga, Latvia, 21st October. 2016. pp. 222.-223.

30. Vecstaudža, J., Ločs, J. Amorfi un mazkristāliski kalcija fosfāti kaulaudu reģenerācijai. Riga Technical University 57th International Scientific Conference, Riga, Latvia, 21st October. 2016.

31. Vecstaudža, J., Gasik, M., Ločs, J. New Biomimetic Amorphous Calcium Phosphate Biomaterials: Structure and Thermal Properties. The 2016 E-MRS Fall Meeting and Exhibition, Poland, Warsaw, 1922 September, 2016.

4.period

1. Vecstaudža, J., Ločs, J. Novel preparation route of stable amorphous calcium phosphate nanoparticles with high specific surface area. Abstracts of the 33rd Scientific Conference of the Institute of Solid State Physics, Latvia, Riga, 22-24 February, 2017, p.121.

2. Vecstaudža, J., Ločs, J. Calcium phosphates with high specific surface area towards improved cell response in vitro. 10th Annual Meeting of Scandinavian Society for Biomaterials: Book of Abstracts, Norway, Hafjell, 15-17 March, 2017, Poster #6.

3. Vecstaudža, J., Ločs, J. Calcium phosphate scaffolds with high specific surface area towards improved cell response in vitro. eCM Meeting Abstracts 2017, Collection 2; TERMIS EU, Switzerland, Davos, 26-30 June, 2017, p.P809.

4. Vecstaudža, J., Ločs, J. Impact of heat treatment on specific surface area of amorphous calcium phosphate. 58th International Conference of Riga Technical University: Materials Science and Applied Chemistry, Riga, Latvia, 20 October, 2017.

5. Vecstaudža, J., Ločs, J. Decrease of specific surface area of amorphous calcium phosphate during gradual heat treatments. 29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine Bioceramics 29: Book of Abstracts, France, Toulouse, 25-27 October, 2017, p.138.

6. Liga Stipniece, Kristine Salma-Ancane, Inga Narkevica, Eriks Jakobsons. Mg-releasing calcium phosphates bioceramic for bone regeneration. Fifth International Conference on Multifunctional, Hybrid and Nanomaterials, Lisabona, Portugāle, 6.-10.marts, 2017. (stenda referāts)

7. Marina Sokolova, JanisLocsandDagnija Loca. Hyaluronanhydrogel/calcium phosphate composites for medical application. 28th Annual Conference of the European Society for Biomaterials, 4-8 September 2017, Athens, Greece (mutiskais referāts).

8. Irbe, Z., Bušs, A., Loča, D., Mālniece, L. Synthesis of Amorphous Calcium Phosphate as a Starting Material for α-Tricalcium Phosphate. 26th International Baltic Conference on Materials Engineering, 26.-27.10.2017., Kauņa, Lietuva. Mutiskais referāts.

9. Ilze Salma, Janis Locs, Girts Salms. Radiological evaluation of bone in animals with experimental osteoporosis after implantation of bioceramic granules. TERMIS -EU, Davos 2017. 06.

10. Mara Pilmane, Ilze Salma, Girts Salms, Kristīne Make, Janis Locs, Dagnija Loca. The influence of Strontium doped biphasic ceramic on the osteoporotic rabbit bone. TERMIS – America, Charlotte, NC, 2017, 3.-6.12. 2017.

11. J. Zarins, M. Pilmane, E. Sidhoma, I. Salma. Bone analysis of strontium doped biomaterials in osteoporotic rabbits: comparison between healthy, osteoporotic and trauma affected bone. Osteoporosis international. Vol 28 (1), 2017. World Congress on osteoporosis, osteoarthritis and musculoskeletal diseases, Florence, Italy, 23.26.03.2017.

12. B. Dalecka, Study of potential PCR Inhibitors in Drinking Water from Riga Distribution System, IWA 9th Eastern European Young Water Professionals Conference, Budapešta, Ungārija, May 24-27, 2017.

13. B. Dalecka, L. Mezule, Study of potential PCR inhibitors in drinking water for Escherichia coli identification. 9th international conference Biosystems Engineering 2018, Tartu, Igaunija, May 9-11, 2018.

14. L. Puķina, E. Blums, D. Zablotsky, Nanoparticle transfer in ferrocolloids in nonuniform magnetic field (poster), EuroNanoforum 2017, Valletta, Malta, 21 - 23 June 2017.

15. V. Sints, E. Blums,Thermophoretic nanocolloid transport in porous environment, (poster), 16th European Student Colloid Conference, Florence, June 19-22, 2017.

16. V. Šints, E. Blūms,G. Kroņkalns, M.M.Majorovs, Surfaktētu nanodaļiņu termiskā pārnese porainā vidē: eksperimentālie pētījumi, LU 75. konference, 2.feb. 2017.

17. M. Majorovs, E. Blūms, G. Kroņkalns Magnetic Nanoparticled Prepared by Spark Discharge, Institute of Solid State Physics, University of Latvia, Abstracts of the 33 Scientific Conference, p.104.

SEMINARS:

1.period

1. 12.01.2015, Scientific workshop of Project No. 4, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Pulka street 3.

3.period

1. RTU Faculty of Materials Science and Applied Chemistry, Institute of General Chemical Engineering, 26.02.2016: Gas adsorbtion. Mearsurement of surface area and pore size using Quadrasorb SI device. Workshop led by: researcher Valentīna Stepanova.

2. RTU Faculty of Materials Science and Applied Chemistry, Institute of General Chemical Engineering, 08.04.2016: Options for processing XRD data. Workshop (discussion) led by: researcher Kristaps Rubenis.

3. University of Latvia, Faculty of Physics and Mathematics, Laboratory of Magnetic Soft Materials has organized 10 scientific workshops under the lead of Professor Andrejs Cēbers.

4.period

1. Lecture in Latvian Academy of Science “Magnetism and Biology”. Workshop (discussion) led by: Prof. A.Cebers.18.04.2018

METHODOLOGIES:

1.period

1. Analytic method for quantitative F- ion determination in the substituted hydroxyapatite structure.

2. Experimental osteoporosis model of rabbits.

3. Cell cultivation.

4. Cell passaging.

5. Cell cryopreservation.

6. Cell defrosting.

7. Cell counting and live cell detection.

8. Cell proliferation evaluation.

9. Method of using superparagnetic particles for viscoelastic measurements with external magnetic field.

10. Method for determination of ferrocolloid transver coefficient (diffusion and Soret effect) in porous environment using nanoparticle concentration distribution in isothermal and non-isothermal porous layers.

2.period

1. Observation of various processes in liquids with different densities by use of microfluidics and tilted microscope. , https://dspace.lu.lv/dspace/handle/7/31152.

1. Determination of diffusion coefficent with fluorescence recovery after photobleaching (FRAP) using constant illumination.

2. Synthesis of magnesium containing calcium phosphates.

3. Synthesis of strontium substituted hydroxyapatite.

4. Preparation and characterization of novel poly(lactic acid)/srontium ranelate microcapsules.

5. Calcium phospahte/hyaluronic acid composite in situ synthesis.

6. Nanosized hydroxyapatite/polyvinyl alcohol composite in situ synthesis.

7. Obtaining calcium phosphate cements and testing their mechanical properties.

8. Characterization of synthesised biomaterials using X-ray diffraction.

9. Biomechanical assessment of osteoporotic mandibular bone after local reinforcement with biphasic calcium phosphate bioceramic materials in femoral trochanter major.

10. Bone volume change measurement in rabbits with and without osteoporosis.

11. The immunohistochemical analysis of biomarkers of healthy and osteoporotic rabbit bone.

TECHNOLOGIES:

3.period

1. The production technology of calcium phosphate nanosuspensions.

2. Preparation of highly porous titanium dioxide ceramic.

3. The production technology of bioceramic granules.

4. Preparation of composites based on hydroxyapatite and ε-polylisine.

4.period

1. Production of nanoparticles by electroeroding metal powders.

2. Production of chemically stable metallic gadolinium (Gd) – noble metal (Au, Ag, Pt, Pd) magnetic nanoparticle composites.

PROTOTYP:

4.period

1. Prototypes for reossification HAP/ β-TCP 70/30 /Sr 5%.

2. Prototypes for reossification HAP/ β-TCP 30/70 /Sr 5%

3. Prototypes for remineralization A.

4. Prototypes for remineralization B.

5. Prototypes for increasing bone volume and mechanical properties A.

6. Prototypes for increasing bone volume and mechanical properties B.

PATENT:

3.period

1. A.Skaģers, I.Šalma, Ģ.Šalms, J.Vētra, S.Petronis, M.Pilmane, J.Ločs, V.Zālīte, Means for bone deffect replacement in the case of osteoporosis (LV 15060 B). Date of patent publication:20.04.2016. Owners: RSU and RTU.

SUMMARY OF RESULTS:

1.Methods for fast monitoring of environmental and food products.

PRODUCT:

4.period

1. Laser tweezers.

EQUIPMENT:

4.period

1. Device for magnetic microrheology research – for determining viscoelastic properties of PF1 gels.

COMERTIAL CONTRACTS:

1.period

1. Contract No. L8174 “SEM-EDX analysis for 10 powder samples” – 605 EUR.

2. Contract No.L8132 “Creation of 3D image for an implant screw” - 1439,90 EUR.

3. Contract No.L8124 “Analysis of samples” – 2000 EUR.

2.period

1. Contract No. L8173 “Testing of samples with UV/Vis” – 653.40 EUR.

2. Contract No.L8215 “Technology development ” – 2795.70 EUR.

3. Contract No.L8218 “Preparation of ceramic samples” – 254.10 EUR.

3.period

1. Contract No. L8247 “Investigation of samples” – 175.00 EUR.

2. Contract No. L8282 “Investigation of samples” – 543.00 EUR.

3. Contract No.L8304 “Investigation of samples” – 968.00 EUR.

4. Contract No. L8331 “Testing of samples” – 1567.00 EUR

POPULAR-SCIENCE PUBLICATION:

2.period

1. Article in journal “Ilustrētā zinātne” – “Microcapsules will help to recover after surgeries” (translated from Latvian) (November, 2015).

3.period

1. Lead. Res., Dr.sc.ing. D.Loča gave an interview on the radio SWH about National Research Programme (IMIS2) Project No. 4 (SWH is one of the most popular radio stations in Latvia).

4.period

1. Participation of Arita Dubņika in popularization of VPP IMIS2 on Latvian Radio 1 (April of 2017).

2. Participation of Ilze Šalma in popularization of VPP IMIS2 on Radio SWH (April of 2017).

3. Participation of Ilze Šalma in popularization of VPP IMIS2 on Latvian Radio 1 (April of 2018).

4. Participation and interview of Linda Mežule in broadcast “Known within Unknown” on Latvian Radio about detection of microorganisms in food and environmental samples (November of 2017).