Identification number: OSI_PIP_BioPhoT-2025/1-0055
Type: National Research Program - BioPhoT project
Duration: 10.2025. - 9.2026.
Project manager: Dr. Viviana Andrea Claveria Pizarro, Institute of Solid State Physics University of Latvia (ISSP UL)
Project partners: Latvian Biomedical Research and Study Centre (BMC)
Total funding: 200 000 EUR
ISSP UL funding: 165 726 EUR
Project Objective:
The main objective of this project is to develop and validate a novel 3D electrode-based deoxyribonucleic acid (DNA) extraction module (GENEX) that enables rapid and reproducible DNA isolation.
Summary:
In molecular diagnostics, DNA extraction remains one of the key bottlenecks, as commercially available methods rely on spun fibre filters or magnetic beads, which either introduce high variability or are difficult to miniaturize. This limits assay reproducibility, increases processing time, and complicates integration into compact systems such as point-of-care diagnostic devices. Within the GENEX project, these challenges are addressed through an interlocked micropillar array based electrode with a tunable electric field, enabling controlled DNA capture and release while ensuring high efficiency and seamless integration into point-of-care platforms.
This project aligns with the RIS3 priority area “Biomedicine, Medical Technologies and Pharmacy.” The expected outcomes include a TRL-4 validated prototype of the DNA extraction module, participation in two international conferences, and the submission of an application to a research and development project call.
PROJECT PROGRESS
Time period: 30.01.2026.
Procurement of required materials is ongoing
Based on material testing results, a flow cell prototype has been developed
Electrode standardization is ongoing
Saliva rheology measurements and optimization of flow simulation parameters for the electrode are ongoing
Market research and business plan development are ongoing
Time period: 30.11.2025.
Procurement of required development materials is underway
The first flow cell design sketch has been created
Electrode standardization has been initiated
Materials have been prepared for material testing
Saliva rheology measurements have been initiated and flow simulation parameters for the electrode are being optimized
Initial market research has been conducted during MEDICA trade fair
The project website has been launched