THE BRIDGE BETWEEN ACADEMIC RESEARCH AND COMMERCIAL-SCALE MANUFACTURING

By translating lab-scale concepts (such as PDMS and 3D prints) into scalable thermoplastic microfluidic devices, the pilot line accelerates the development of advanced diagnostic systems, biosensors, and lab-on-a-chip technologies.

 

■ CERTIFIED INFRASTRUCTURE: ISO 9001 and ISO 14644 certified 650 m² cleanrooms fit for high-precision manufacturing.

■ RECORD OF SUCCESS: Delivered on 30+ microfluidics projects in partnership with academia and industry.

■ NO SCALING BOTTLENECKS: Limited early-stage tooling expenses and easily transferable PDMS designs.

 


 Application areas:

 

■ Biomedical and clinical diagnostic devices

■ Sample preparation devices

■ Biosensors and integrated lab-on-a-chip systems

■ Organ-on-a-chip and advanced cell culture platforms

■ Environmental and food safety testing instruments

 Target audiences:

 

■ Biotech startups focusing on diagnostics and lab-on-a-chip solutions

■ Academic and institutional research teams

■ University and institute spin-offs

■ Small and medium-sized enterprises (SMEs) transitioning to thermoplastic manufacturing


 The Scale-Up Pathway

 

Go from initial lab concepts to manufacturable polymer microfluidics in three development stages:

1. Design-for-Manufacturing (DfM)
2-4 weeks  •  Rapid Prototyping
Conversion of academic layouts (PDMS, 3D prints) into injection-molding designs. Rapid iteration using OSTE-COC bonded chips (75.5 × 25.5 mm footprint) for early-stage validation.

2. Custom Insert Molding
3-8 months  •  Pilot Production
Production of 10 to 10,000 units utilizing modular aluminium or steel tool inserts – validating performance in the real world without full-scale tooling capital expenditure.

3. Custom Microfluidics
6+ months  •  High-Precision Scale-Up
Fully customized geometries and parts up to a 12g shot size using dedicated Zhafir ZE 400-5 micro-injection molding equipment.

MINIMUM FEATURE SIZEDown to ~10 µm
PRIMARY MATERIALSCOC, COP
OTHER SUPPORTED MATERIALSPC, PMMA, PS, PP, PE, ABS
CORE CAPABILITIESMicro-injection molding, cleanroom production, bonding & assembly
KEY EQUIPMENTZhafir ZE 400-5 injection molding system with modular mold base
 

Ģirts Ozoliņš
Senior Expert in Innovations & Commercialization
girts.ozolins@cfi.lu.lv

 

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